In most animals, a three-chambered heart that allows blood from the lungs to mix with blood from the body systems would be very inefficient. Why does it work well for amphibians?

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 A three-chambered heart works well for amphibians because of their unique respiratory system and lifestyle. Here's why:

     Amphibians can breathe through their skin (cutaneous respiration) in addition to using lungs. This means that not all oxygen needs to be delivered through the lungs and circulated by the heart — oxygen can also enter the bloodstream directly through the skin.

      Their metabolic rate is relatively low, so their bodies do not require a high rate of oxygen delivery like mammals or birds.

     Amphibians often live both in water and on land (they are semi-aquatic), so having some mixing of oxygenated and deoxygenated blood is less of a disadvantage in their environment and lifestyle.

      So, although the three-chambered heart is less efficient in separating oxygen-rich and oxygen-poor blood, amphibians’ dual respiratory system and lower oxygen demand make this system effective enough for them.